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Novel 2019 Coronavirus structure part 11

A different two-step mechanism has been suggested and in this case  the virions binds to a receptor on the target host cell surface through its S1 subunit and the spike  is cleaved by host proteases and then it is expected … Continue reading

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Novel 2019 Coronavirus structure part 10

Searching for antibodies can find support on molecular targeting  which can utilize the structural information  (aa sequence) of the binding region  which is found in angiotensin-converting enzyme 2 receptor. In this way this protocol could device a treatment to block … Continue reading

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Novel 2019 Coronavirus structure part 7

The E-protein is a small membrane protein  composed ∼76 to 109 amino-acid and minor component of the virus particle, it plays an important role in virus assembly, membrane permeability of the host cell and virus-host cell interaction. A lipid envelop … Continue reading

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Novel 2019 Coronavirus structure part 6

The M-protein is most abundant in the viral surface and it is believed to be the central organizer for the coronavirus assembly. The S-protein is integrated over the surface of the virus, it mediates attachment of the virus to the … Continue reading

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Emerging coronaviruses part 12

Diversity of CoV pathogenesis Different CoVs display diverse host range and tissue tropism. Usually, alphacoronaviruses andbetacoronaviruses infect mammals. In contrast, gammacoronaviruses and deltacoronaviruses infect birds and fish, but some of them can also infect mammals. Before 2019, there were only … Continue reading

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Emerging coronaviruses part 11

Four structural proteins are essential for virion assembly and infection of CoVs. Homotrimers of S proteins make up the spikes on the viral surface and they are responsible for attachment to host receptors. The M protein has three membrane domains … Continue reading

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Emerging coronaviruses part 10

FUNCTIONS OF NONSTRUCTURAL AND STRUCTURAL PROTEINS IN CORONAVIRAL REPLICATION Most of the nsps of nsp-16 have been reported for their specific roles in the replication of CoVs. However, the functions of some of the nsps are unknown or not well … Continue reading

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Emerging coronaviruses part 9

The maintenance  of such a large genome of CoVs may be related to the special features of the CoV RTC, which contains several RNA processing enzymes such as the 3′-5′ exoribonuclease of nsp14. The 3′-5′ exoribonuclease is unique to CoVs … Continue reading

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Emerging coronaviruses part 1

Coronaviruses (CoVs) are important pathogens for human and vertebrates. They can infect respiratory, gastrointestinal, hepatic, and central nervous system of human, livestock, birds, bat, mouse and many other wild animals. The outbreaks of the severe acute respiratory syndrome (SARS) in … Continue reading

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Continuous and discontinuous RNA synthesis in coronaviruses part 44

Arterivirus nsp1 and N proteins also localize in the cytoplasm and the nucleus of infected cells. Porcine reproductive and respiratory syndromevirus (PRRSV) N protein accumulates in the nucleoli of infected cells, where it interacts with the host cells proteins fibrillarin, … Continue reading

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