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Imaging of coronavirus disease 2019 part 25

Some researchers have tried to apply artificial intelligence in CT image analysis to differentiate COVID-19 from other viral pneumonia patients. With clinical symptoms, laboratory testing results, and contact or travel history, the artificial intelligence system can help doctors identify patients … Continue reading

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Imaging of coronavirus disease 2019 part 16

The lesion range can be acinar, leaflet, lung segment or lung lobe. Lesions are distributed as bilateral asymmetrical¬† subpleural wedge-shaped or fan-shaped, mostly in the caudal lesions of the lung and dorsal subpleural area. When interlobular septa and intralobular interstitium … Continue reading

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Imaging of coronavirus disease 2019 part 15

Disease progression mostly occurs in course of 7-10 days, with enlarged and increased density of GGO, and consolidated lessions with air bronchogram sign. GGOs from the early stage expand, and the density increases gradually. Consolidation shows increased lung parenchimal density, … Continue reading

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Imaging of coronavirus disease 2019 part 13

Typical features on chest X-Ray Multiple small patchy shadows and interstitial changes in the lower zone of lungs are typical imaging features in common type patients. With the progression of the disease, it may manifest as a patchy distribution or … Continue reading

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Novel 2019 Coronavirus structure part 28

Cao et al. have conducted trial test using lopinavir-ritonavir drugs for COVID-19 patients. They found that lopinavir-ritonavir treatment failed to significantly accelerate clinical improvement, reduce mortality, diminish throat viral RNA detectability in patients with serious COVID-19. In case of the … Continue reading

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Novel 2019 Coronavirus structure part 26

In a short time, the response of the scientific community is such that involve enormous efforts to develop a novel therapy and treatment. For example, chloroquine and hydroxychloroquine,¬† old drugs, have been used to treat malarial, rheumatoid arthritis, lupus and … Continue reading

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Novel 2019 Coronavirus structure part 24

Further, it can form several hydrogen bonds with the main chain of the residues in the substrate-binding pocket. Several X-ray studies demonstrated that the small antiviral compound including lopinar is locked in the same position of N3 in the substrate-binding … Continue reading

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Novel 2019 Coronavirus structure part 23

Recently, Jin et al., have constructed a homology model for COVID-19 main protein and they used molecular docking to monitor whether the N3 binds with it. The docking showed that N3 binds with the COVID-19 main protease. Subsequently, the crystal … Continue reading

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Novel 2019 Coronavirus structure part 22

Small molecules interact with COVID-19 main protease Yang et al., have designed Michael acceptor N3 inhibitors are found to have an optimal pharmaceutical activity against viral protease through mechanism-based irreversible inhibition. They also evaluated a series of wide-spectrum inhibitors targeting … Continue reading

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Novel 2019 Coronavirus structure part 18

E-protein is involved in several¬† aspects of the virus life cycle, such as assembly, budding, envelope formation and pathogenesis. E protein’s ion channel activity is found in the transmembrane region of the protein. The membrane potential has been regulated by … Continue reading

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