Blog Archives

Continuous and discontinuous RNA synthesis in coronaviruses part 23

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Continuous and discontinuous RNA synthesis in coronaviruses part 20

This interaction could bring into physical proximity the leader sequence, at the genome 5’end, and the TRS-N, which would promote the template switch during synthesis of the negative-strand sgRNAs. This long-distance RNA-RNA interaction provided for the first time experimental support … Continue reading

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Continuous and discontinuous RNA synthesis in coronaviruses part 18

  In TGEV, two intragenomic, long-distance RNA-RNA interactions have been described to regulate the transcription of sgmRNA [coding for the nucleocapsid protein (N protein)], which is the most abundant sgmRNA during viral infection despite its low ΔG value for TRS-L-TRS-B … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 44

Based on these observations, the investigation hypothesized that exposure to one of the two viruses could elicit cross-reactive and potentially neutralizing Abs against the other virus. The investigation therefore investigated the ability of plasma from mice immunized with a stabilized … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 3

  The SARS CoV-2 spike glycoprotein harbors a furin cleavage site at the boundary between the S1/S2 subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. Cryo-EM structures of the SARS-CoV-2 spike ectodomain … Continue reading

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Structures and functions of Coronavirus proteins part 10

  S Glycoproteins S glycoproteins are located outside the virion and give the virion the typical shape. The S protein form  homotrimers, which allow the formation of sun-like morphologies that give the name of Coronavirus. S proteins bind to virion … Continue reading

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Human coronaviruses part 36

Based on genomic sequence analysis, these bat coronaviruses were grouped  into lineage C  of the genus Betacoronavirus. After the outbreak of MERS, MERS-CoV related coronavirus were found in more bat species and countries. Among these viruses, full-length or near full-length … Continue reading

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Interventions to improve preterm birth outcomes part 7

  The recommendation: The benefits to the preterm infants In terms of reducing early morbidity and mortality outcomes The low cost and wide availability of corticosteroid The feasibility of implenting the intervention The potential impact on health-care resource     … Continue reading

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Interventions to improve preterm birth outcomes part 6

  Essential and special care for the management of preterm newborns should be available to prevent or address any newborn complications related to prematurity.

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Interventions to improve preterm birth outcomes part 2

  Antenatal corticosteroid therapy is recommended for women at risk of preterm birth from 24 weeks to 34 weeks of gestation when the following condition are met: Gestational age assessment can be accurately undertaken Preterm birth is considered imminent There … Continue reading

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