Category Archives: Tak Berkategori

Protein-based subunit vaccines More about Hepatitis B vaccines The first available hepatitis B vaccines were plasma-derived, produced by harvesting hepatitis B surface antigen (HBsAg) from the plasma of persons with chronic HBV infection. The particles are highly purified, and any … Continue reading →

Protein-based subunit vaccines More about Pertussis vaccine Both acellular (aP) and whole-cell pertussis (wP) vaccines are safe and effective. In terms of rare, more severe adverse reactions, aP and wP vaccines appear to have the same high level of safety. … Continue reading →

Protein-based subunit vaccines Adverse reactions associated with subunit protein-based vaccines Acellular pertusis (aP) Same as tetanus and diptheria toxoid vaccines Acellular pertusus-containing vaccines are less reactogenic in terms of mild-to-moderate reactions than wP-containing vaccines Hepatitis B (HepB) Very rare Reports … Continue reading →

Protein-based subunit vaccines Commonly used protein-based subunit vaccines are the following: Acellular pertusis (aP) vaccines contain inactivated pertussis toxin (protein) and may contain one or more other bacterial components. The pertusis toxin is detoxified either by treatment with a chemical … Continue reading →

Protein-based subunit vaccines Protein based subunit vaccines present an antigen to the immune system without viral particles, using a specific, isolated protein of the pathogen. A weakness of this technique is that isolated proteins, if denatured, may bind to different … Continue reading →

Subunit vaccines Subunit vaccines can be further categorized into: Protein -based subunit vaccines Polysaccharide vaccines Conjugate subunit vaccines

Subunit vaccines: Safety and stability Like inactivated vaccines, subunit vaccines do not contain live components and are considered as very safe. Immune response: Must determine which combination of antigenic properties will produce an effective immune response with the correct pathway … Continue reading →

Subunit vaccines Immune response: Subunit vaccines, like inactivated whole-cell vaccines do not contain live components of the pathogen. They differ from inactivated whole-cell vaccines, by containing only the antigenic parts of the pathogen. These parts are necessary to elicit a … Continue reading →

Inactivated whole-cell vaccines Safety and stability: Inactivated whole-cell vaccine have no risk of inducing the disease they are given against as they do not contain live components They are considered more stable than LAV vaccines.

Inactivated whole-cell vaccinations Immune response: Inactivated-whole cell vaccines may not always induce an immune response and the response may not be long lived Several doses of inactivated whole-cell vaccines may be required to evoke a sufficient immune response