Category Archives: Tak Berkategori

  The receptor-binding S1 subunit of coronavirus spike proteins contain two distinctive domains, the N-terminal domain (S1-NTD) and the C-terminal domain (S1-CTD), both of which can function as receptor-binding domains (RBDs). S1-NTDs and S1-CTDs from three major coronavirus genera recognize … Continue reading →

  Receptor recognition by viruses  is the first and essential step of viral infection of host cells. It is important determinant of viral host range and cross-species infection and a primary target for antiviral intervention. Coronaviruses recognize a variety of … Continue reading →

  With human activity increasingly overlapping the habitats of bats, diseases outbreaks resulted   from spillover of bat coronaviruses will continue to occur in the future despite the fact that direct transmission of bat coronaviruses to humans  appears to be rare. … Continue reading →

  The spike protein and host receptor are key factors of cross-species transmission of coronaviruses, characterization of the receptor and key binding sites of the spike protein will be important in estimating host tropism of bat coronaviruses and predicting spillover … Continue reading →

  Bats are likely natural reservoirs of MERS-CoV or an ancestral MERS-like CoV. It is hypothesized that bat MERS-like CoV jumped to camels or some other as yet unidentified animal several decades ago. The virus evolved and adapted with accumulating  … Continue reading →

  Bats harbor coronaviruses  with great genetic diversity. It is believed that most, if not all, currently circulating alphacoronaviruses and betacoronaviruses in different mammals are evolutionally linked to ancestral coronaviruses  originated from bats. Different species of rhinolophid bats  in China … Continue reading →

  Although the study of bat-borne coronaviruses has only started just about 15 years ago, the scientific community has already learnt a great deal of useful lessons which will be instrumental in mitigating , predicting, and preventing future zoonotic coronavirus … Continue reading →