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Clinical use of stem cells in orthopaedics part 56

  Along with bone marrow mesenchymal stem cells, adipose stem cells have received attention for cartilage regeneration. Extensive investigations on chondrogenesisfrom adipose stem cells in the last 15 years provided the basis of clinical application (Zuk et al., 2001). As … Continue reading

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Clinical use of stem cells in orthopaedics part 55

  The ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymals on osteoarthritic changes in the knee were investigated in 55 patients. A single injection (50×10[6] or 150×10[6] allogeneic) was given within … Continue reading

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Clinical use of stem cells in orthopaedics part 54

  Another group analysed  the use of intra-articular injections of cultured  autologous bone marrow mesenchymal stem cells in conjuction with microfracture and medial opening-wedge high tibial osteotomy  Fifty-six knees in 56 patients with unicompartmental osteoarthritic knees and genu varum were randomly … Continue reading

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Clinical use of stem cells in orthopaedics part 53

  Wakitani et al. applied bone marrow mesenchymal cells to repair human articular cartilage defects in osteoarthritic knee joints as an additional procedure to a high tibial osteotomy. In 24 knees, of 24 patients with knee osteoarthritis, culture-expanded mesenchymal stem … Continue reading

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Clinical use of stem cells in orthopaedics part 52

  In two individual case reports of cartilage degeneration of knee, Centeno et al. (Centeno et al., 2008a; Centeno et al., 2008b) demonstrated statistically significant changes  in visual analogue-scale pain scores and cartilage volumes on MRI. Davatchi et al. reported … Continue reading

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Clinical use of stem cells in orthopaedics part 51

  Stem cells to treat osteoarthritis Osteoarthritis presents a greater pool of affected patients than osteochondral defects. Following the promising results of in vivo implantation of stem cells in large animal models of osteoarthritis, sporadic case series began to be … Continue reading

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Clinical use of stem cells in orthopaedics part 50

  In summary, most reports describe good results of mesenchymal implantation in treating cartilage defects, including symptomatic and functional improvement  as well filling of defects. On the other hand, histological  analysis indicates that true hyaline cartilage is rarely found in … Continue reading

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