Author Archives: azaleaazelia

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Continuous and discontinuous RNA synthesis in coronaviruses part 3

  Coronavirus RNA synthesis is connected with formation of double-membrane  vesicles  and convoluted membranes. Coronavirus encode proofreading machinery, unique in the RNA virus world, to ensure the maintenance of their large genome size.

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Continuous and discontinuous RNA synthesis in coronaviruses part 2

  Coronavirus RNA synthesis is performed by a replication-transcription complex that includes viral and cell proteins that recognize cis-acting RNA elements  mainly located in the highly structured 5′ and 3′ untranslated regions. In addition to many viral nonstructural proteins, the … Continue reading

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Continuous and discontinuous RNA synthesis in coronaviruses part 1

  Replication of the coronavirus genome requires continuous RNA synthesis, whereas transcription is a discontinuous process unique among RNA viruses. Transcription includes a template switch during the synthesis of subgenomic negative-strand RNAs to add a copy of the leader sequence. … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 58

  These findings also indicate that it might be difficult to distinguish exposure to SARS-CoV-2 from other SARSr-CoVs in serological studies using S ectodomain trimers and that specific assays will need to be designed. The investigation results provide structural framework … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 57

  The investigation note that most SARS-CoV neutralizing Abs  isolated to date target the SB domain and that several of them recognize the RBM and prevent receptor engagement. As the SARS-CoV-2 and SARS-CoV SB domains share  75% amino acid sequence … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 56

  The investigation surmise most of these Abs target the highly conserved S2 subunit  (including the fusion peptide region) based on its structural similarity  across SARS-CoV-2 and SARS-CoV, the lack of crosss-reactivity of several SB-directed Abs, and previous reports showing … Continue reading

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 55

  The striking structural similarity and sequence conservation among the SARS-CoV-2 S and SARS-CoV S glycoproteins emphasize the close relationship between these two viruses that recognize hACE2 to enter target cells. This resemblance is further strengthened by investigation finding that … Continue reading

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