Author Archives: azaleaazelia

About azaleaazelia

A nice person... :)

CHRONIC LYMPHOCYTIC LEUKEMIA part 22

  SUMMARY REMARKS ON THE DEVELOPMENT, GROWTH, AND EVOLUTION OF  B-CLL On the basis of the foregoing information, we propose a model for the development of B-CLL. B-CLL cells are able to avoid apoptosis and even to proliferate by receiving … Continue reading

Posted in Tak Berkategori | Leave a comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 21

  These considerations are in line with the results of in vivo labeling experiments that involve incorporation of nonradioactive deterium into newly synthesized DNA of dividing cells. These studies have shown B-CLL clones to be dynamic, having measurable birth rates … Continue reading

Posted in Tak Berkategori | Leave a comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 20

  Similarly, there is a rough correspendence between the clinical course of patients  and the development of chromosomal abnormalities in their clones. Recurrent  chromosomal lesions typically found in B-CLL patients include deletion at 13q14.3,11q22-23,17p13, and 6q21, and amplifications of all … Continue reading

Posted in Tak Berkategori | Leave a comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 19

  CORRELATIONS BETWEEN THE CELLULAR AND MOLECULAR FEATURES OF THE DISEASE WITH THE CLINICAL COURSE OF B-CLL How might features of the repertoire of IgVH genes used by B cells in B-CLL, the mutations status of these genes, and expression … Continue reading

Posted in Tak Berkategori | 1 Comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 18

  In addition to antigen stimulation, B-CLL cells also receive receptor-mediated signals as well as soluble factors, such as cytokines and chemokines, from other lymphoid and nonlymphoid cells. In particular, it is thought that in vivo B-CLL cell interactions with … Continue reading

Posted in Tak Berkategori | Leave a comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 17

  A hypothesis such as this implies that it might be possible to detect  clonal expansions in healthy subjects. In fact, small numbers of apparently clonal B cells with B-CLL cell characteristics do exist in the blood of about 3.5% … Continue reading

Posted in Tak Berkategori | 1 Comment

CHRONIC LYMPHOCYTIC LEUKEMIA part 16

  With continued expansion leading (or not) to accumulation of IgVH gene mutations as explained by the T-cell-dependent versus T-cell-independent models mentioned earlier, it becomes increasingly likely that a cell develops a genetic abnormality as in an initial inducing lesion … Continue reading

Posted in Tak Berkategori | Leave a comment