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Clinical use of stem cells in orthopaedics part 14

    Studies to date show the safety of using autologous¬† human mesenchymal stem cells for bone regeneration in segmental long-bone defects. None of the reports mention adverse effects, such as inflammation or excessive tissue growth. In view of the … Continue reading

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Clinical use of stem cells in orthopaedics part 13

  The first clinical case report described three patients with various segmental long bone defects who underwent implantation of autologous mesenchymal stem cells. Macroporous 100% hydroxyapatite scaffolds, which were made to fit the shape and size of the defect, were … Continue reading

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Clinical use of stem cells in orthopaedics part 12

  Most reported human studies of stem cell-based bone regeneration are cohort outcome studies or case reports, because of the practical and ethical issues involved in conducting a randomised controlled trial. Published human clinical studies¬† or case reports used autologous, … Continue reading

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Clinical use of stem cells in orthopaedics part 11

  To fascilitate regeneration of currently intractable large bone defects, stem cell therapy has emerged as a possible solution. Bone marrow injection, in a sense, represents a primitive form of stem cell therapy. The method had been used to treat … Continue reading

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Clinical use of stem cells in orthopaedics part 10

  To treat a large bone defect, harvesting a large portion of bone from other parts of the body inevitably creates significant morbidity at the donor site. Allografts from cadavers carry a risk of infection and disease transmission, as well … Continue reading

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Clinical use of stem cells in orthopaedics part 9

  Stem cells for treating long-bone defects Bone is one of the most frequently transplanted tissues. Unlike other tissues, complete regeneration occurs after bone injury, rather than healing with scar tissue. While most bone defects heal spontaneously or with autogenous … Continue reading

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Clinical use of stem cells in orthopaedics part 8

  Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of … Continue reading

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