Author Archives: azaleaazelia
Protein-based subunit vaccines Adverse reactions associated with subunit protein-based vaccines Acellular pertusis (aP) Same as tetanus and diptheria toxoid vaccines Acellular pertusus-containing vaccines are less reactogenic in terms of mild-to-moderate reactions than wP-containing vaccines Hepatitis B (HepB) Very rare Reports … Continue reading
Protein-based subunit vaccines Commonly used protein-based subunit vaccines are the following: Acellular pertusis (aP) vaccines contain inactivated pertussis toxin (protein) and may contain one or more other bacterial components. The pertusis toxin is detoxified either by treatment with a chemical … Continue reading
Protein-based subunit vaccines Protein based subunit vaccines present an antigen to the immune system without viral particles, using a specific, isolated protein of the pathogen. A weakness of this technique is that isolated proteins, if denatured, may bind to different … Continue reading
Subunit vaccines Subunit vaccines can be further categorized into: Protein -based subunit vaccines Polysaccharide vaccines Conjugate subunit vaccines
Subunit vaccines: Safety and stability Like inactivated vaccines, subunit vaccines do not contain live components and are considered as very safe. Immune response: Must determine which combination of antigenic properties will produce an effective immune response with the correct pathway … Continue reading
Subunit vaccines Immune response: Subunit vaccines, like inactivated whole-cell vaccines do not contain live components of the pathogen. They differ from inactivated whole-cell vaccines, by containing only the antigenic parts of the pathogen. These parts are necessary to elicit a … Continue reading
Inactivated whole-cell vaccines Safety and stability: Inactivated whole-cell vaccine have no risk of inducing the disease they are given against as they do not contain live components They are considered more stable than LAV vaccines.
Inactivated whole-cell vaccinations Immune response: Inactivated-whole cell vaccines may not always induce an immune response and the response may not be long lived Several doses of inactivated whole-cell vaccines may be required to evoke a sufficient immune response
Inactivated whole-cell vaccinations Inactivated vaccines are made from microorganism (viruses, bacteria, other) that have been killed through physical or chemical process. These killed organisms cannot cause disease.
Yellow fever (YF): Hypersensitivity reactions Very rare Sensitivity to egg, which is commonly used to stabilize the vaccine, may explain at least some of these cases 2. Vaccine-associated neurotropic disease (encephalitis) Very rare Infants seem more susceptible to vaccine-associated neurotropic … Continue reading