Author Archives: azaleaazelia
Finally, transfer of human B-CLL cells into immune-deficient mice may bypass the ex vivo apoptosis tendency of B-CLL cells, enabling their survival and amplification in vivo. Such an approach may also make it possible to define and test new … Continue reading
In the third tramsgenic model, overexpression of APRIL (a proliferation inducing ligand ) in murine T cells leads indirectly to B-cell proliferation and survival because of signaling through its receptors BCMA and TACI. Unlike the previous two transgenic animals, … Continue reading
Another mouse model that develops features resembling human B-CLL involves the overexpression of two genes: BCL-2 and TRAFT2 (TNF-receptor-associated factor 2). This double transgenic animal is especially intriguing because of the already mentioned recent work showing that the deletion … Continue reading
Transgenic mice expressing the TCL1 gene in murine B cells develop a polyclonal expression of B lymphocytes early in life that becomes progressively more restricted until a monoclonal population emerges after about one year in most animals. The genetic … Continue reading
In recent years, however, a variety of transgenic mouse models have been developed that lead to diseased phenotypes resembling human B-CLL more closely and reproducibly. We focus on three models that have been especially helpful.
ANIMAL MODELS OF B-CLL While an enormous amount of new information has been gleaned by directly studying human B-CLL cells, animal models are now contributing to our understanding of the human disease. For example, New Zealand Black (NZB) mice … Continue reading