Author Archives: azaleaazelia

  Several controlled studies have been published recently on the application bone marrow aspirate concentrations to treat osteonecrosis of the femoral head, most of which reported a beneficial effect  of the implantation of bone marrow aspirate concentrations or culture-expanded mesenchymal … Continue reading →

  A method that induces bone regeneration with minimal surgical intervention is needed  for those young patients. Hernigou et al. first hit on the idea of cell therapy for osteonecrosis of the femoral head. They added bone marrow aspirate concentrate … Continue reading →

  In rotational osteotomy, the proximal femur is osteotomised and rotated along the axis of the femoral neck, so that the uninvolved posterior portion becomes the superior weight-bearing area. This operation has not been popularised outside of Japan due to … Continue reading →

  In core decompression, part of necrotic bone is removed to decompress the intramedullary pressure and thereby relieve pain. Because of the relative insufficiency of osteoprogenitor cells in the proximal femur of the osteonecrotic hip, the bone defect thus created … Continue reading →

  Application of stem cells for osteonecrosis Osteonecrosis of the femoral head is the death of osteocytes and subsequent structural change leading to collapse of femoral head and secondary osteoarthritis of the hip joint. Osteonecrosis of the femoral head occurs … Continue reading →

  In summary, because of challenging nature of constructing a viable cell-scaffold composite, clinical application of stem cell is still in its incipient stage. Sporadic reports describe the application of mesenchymal stem cells from bone marrow or adipose tissue along … Continue reading →

  Recently, Dufrane et al. reported use of scaffold-free three-dimensional grafts from autologous adipose stem cells for reconstruction of large-bone defects. Human adipose stem cells were obtained from subcutaneous adipose tissue of six patients, expanded up to passage 4, incubated … Continue reading →