Author Archives: azaleaazelia

  Prototypic α-genus coronaviruses include human coronavirus NL63(HCoV-NL63), porcine transmissible gastroenteritis coronavirus (TGEV), and porcine respiratory coronavirus (PRCV). Prototypic β-genus coronaviruses include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV), mouse hepatitis coronavirus (MHV), and bovine … Continue reading →

  Coronaviruses belong to the Coronaviridae family in the order of Nidovirales. They can be classified into at least three major genera, α, β, γ (formerly group 1, 2, and 3, respectively).

  Coronaviruses are a group of common, ancient, and diverse viruses. They infect many mammalian and avian species and cause respiratory, gastrointestinal and central nervous system diseases. Coronavirus virions contain an envelope, a helical capsid, and single-stranded and positive-sense RNA … Continue reading →

  The receptor-binding S1 subunit of coronavirus spike proteins contain two distinctive domains, the N-terminal domain (S1-NTD) and the C-terminal domain (S1-CTD), both of which can function as receptor-binding domains (RBDs). S1-NTDs and S1-CTDs from three major coronavirus genera recognize … Continue reading →

  Receptor recognition by viruses  is the first and essential step of viral infection of host cells. It is important determinant of viral host range and cross-species infection and a primary target for antiviral intervention. Coronaviruses recognize a variety of … Continue reading →

  With human activity increasingly overlapping the habitats of bats, diseases outbreaks resulted   from spillover of bat coronaviruses will continue to occur in the future despite the fact that direct transmission of bat coronaviruses to humans  appears to be rare. … Continue reading →

  The spike protein and host receptor are key factors of cross-species transmission of coronaviruses, characterization of the receptor and key binding sites of the spike protein will be important in estimating host tropism of bat coronaviruses and predicting spillover … Continue reading →