Types of vaccine part 38

Combination vaccines

It is very important, however, that combination vaccines are carefully tested before introduction. For instance, adjuvants in a combination vaccine could reduce the activity of one antigen and excessively increase the reactivity of another antigen. There could also be interactions with other vaccine components such as buffers, stabilizers and preservatives.

With all combinations, manufactures must therefore evaluate the potency of each antigen component, the effectiveness of the vaccine components when combined to induce immunity, risk of possible reversion to toxicity, and reaction with other vaccine components.

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