Types of vaccine part 6

Safety and stability:

  • Attenuated pathogens can revert to original form and cause disease
  • Potential harm to individuals with compromised immune systems (eg. HIV)
  • Sustained infection (BCG-local lymphadenitis)
  • Contamination of tissue culture
  • Immunization errors (Reconstitution, cold chain)
  • Usually not given in pregnancy

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