What are viral vector-based vaccines and how could they be used against COVID-19?
How easy are they to manufacture?
A major bottleneck for viral vector vaccine production is scalability. Traditionally, viral vectors are grown in cells that are attached to a substrate, rather than in free-floating cells-but this is difficult to do on a large scale. Suspension cell lines are now being developed, which would enable viral vectors to be grown in large bioreactors. Assembling the vector vaccine is also a complex process, involving multiple steps and components, each of which increases the risk of contamination. Extensive testing is therefore required after every step, increasing costs.