How do whole virus vaccines trigger immunity?
Inactivated virus vaccines also contain the disease-causing virus, or parts of it, but their genetic material has been destroyed. For this reason, they are considered safer and more stable than live attenuated vaccines, and they can be given to people with compromised immune systems. Even though their genetic material has been destroyed, inactivated viruses usually contain many proteins which the immune system can react to. But because they cannot infect cells, inactivated vaccines only stimulate antibody-mediated responses, and this response maybe weaker and less long-lived. To overcome this problem, inactivated vaccines are often given alongside adjuvants (agents that stimulate the immune system) and booster doses may be required.