Some critically patients may have elevation of troponin level, and an increase of C-reactive protein can be seen. Critically ill patients may develop acute respiratory distress syndrome, septic shock with metabolic acidosis and coagulation dysfunction that are difficult to correct. For the clinical criteria, the first step is to ascertain the epidemiology history  of suspected cases. Confirmed cases must be tested positive by RT-CPR assay or by NGS. SARS-CoV-2 nucleic acids can be detected in nasopharingeal swabs, sputum, or other lower respiratory tract secretions, blood, and stools.