In a short time, the response of the scientific community is such that involve enormous efforts to develop a novel therapy and treatment. For example, chloroquine and hydroxychloroquine, old drugs, have been used to treat malarial, rheumatoid arthritis, lupus and sun allergies for more than sixty years. The activity of hydroxychloroquine on viruses is probably same as that of chloroquine since the mechanism of the action of these two molecules is identical. Chloroquine as an antimalarial and autoimmune disease drugs shown a synergically enhancing effect as antiviral drugs in vivo studies. It interferes with terminal glycosylation of cellular receptor, angiotensin-converting enzyme 2. This may negatively influence-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting the spread of SARSCoV in cell culture has been prevented.