Wilson et al., showed that hexamethylene amiloride inhibitor has shown to block the E-protein ion channel conductance in cell membrane and inhibits replication of the parent coronavirus in cultured cells. Recently, Gupta et.al, have identified  the medicinal properties of Belachinal, Macaflavanone E and Vibsanol B inhibitors which are successfully passed the ADMET test and Lipinski’s rule 5s. These compounds are reduced the random motion of the human COV ID-19 E protein in terms of inhibiting the function of the human COVID-19 E” protein.