Novel 2019 Coronavirus structure part 19

Few efforts have been found that mutation of the E-protein in the extracellular membrane could disrupt the ion-conductivity and the normal viral assembly, hence control the E-protein dynamics is a promising target for preventing pathogenesis associated with the COVID-19. For example, Nieto-Torres eat al. have demonstrated that, mice infected with COVID-19    viruses exhibited  E-protein ion channel activity, with wild-type E-protein sequence, that restore ion transport, resulting in the mice death with the loss of weight.   

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