The Chinese scientists have first published the genome and with overseas collaboration have obtained the crystal structure of three-dimensional novel COVID-19 main protease and deposited in the protein data bank. The crystal structure of COVID-19 main protease has 306 amino acids with the three regions, in the first region contains 8-101 residues, second region in are 102-184 residues and third region are 201-303 residues.  The first and third regions have an antiparallel β-sheet structure, third region has five alpha helices arranged into a cluster. The third region is connected to second region through a long loop region contains 185-200 residues