In the cytoplasm nucleocapsids are formed from endoplasmic reticulum-Golgi intermediate compartement (ERGIC) the encapsidation of replicated genomes by N protein, and as a result they coalesce within the endoplasmic reticulum-golgi intermediate compartement (ERGIC) membrane in order to self-assembly into new virions. Finally, novel virions are exported from infected cells by transport to the cell membrane in smooth-walled vesicles and then secreted via a process called exocytosis, so that can infect other cells. In the meantime, the stress of viral production on the endolasmic reticulum eventually leads to cell death. However, the mechanism of action for novel COVID-19 is still unknown.