Novel 2019 Coronavirus structure part 12

Replication/transcription complex (RTC) is encoded in the viral genome and it is made of non structural proteins (nsp). The RTC is believed to induced double-membrane structures in the cytoplasm of the infected cell. Following the positive RNA genome is translated to generate replicase proteins frome open reading frame 1a/b (ORF 1ab). These proteins use the genome as a template to generated full-length negative sense RNAs, which subsequently serve as templates in generating addition full-length genomes. Structural viral proteins , M, S and E are synthesized in the cytoplasm and then inserted into the endoplasmic reticulum (ER), and transfer to endoplasmic reticulum-Golgi intermediate compartement

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