The coronavirus spike (S) protein attaches to angiotensin converting enzyme 2 (ACE2) receptors that is found on the surface of many human cells, including those in the lungs allowing virus entry. The coronavirus S protein is subjected to proteolytic cleavages by host proteases (i.e. trypsin and furin), in two sites located at the boundary between the S1 and S2 subunits (S1/S2 site). In a later stage happens the cleavage of the S2 domain (S2′ site) in order to release the fusion peptide. This event will trigger the activation of the membrane fusion mechanism.