Emerging coronaviruses part 5

Subsequently, a nested set of subgenomic RNAs (sgRNAs) are synthesized by RTC in a manner of discontinuous transcription. These subgenomic messenger RNAs (mRNAs) possess common 5′-leader and 3′-terminal sequences. Transcription termination and subsequent acquisitio nof a leader RNA occurs at transcription regulatory sequences, located between open reading frames(ORFs). These minus-strand sgRNAs serve as the templates for the production of subgenomic mRNAs.

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