Coronaviruses (CoVs) are important pathogens for human and vertebrates. They can infect respiratory, gastrointestinal, hepatic, and central nervous system of human, livestock, birds, bat, mouse and many other wild animals. The outbreaks of the severe acute respiratory syndrome (SARS) in 2002/2003 and the Middle East respiratory syndrome (MERS) in 2012 have demonstrated the possibility of animal-to-human and human-to-human transmission of newly emerging CoVs. An outbreak of mystery pneumonia in Wuhan since Desember 2019 has been drawing tremendous attention around the world.