Continuous and discontinuous RNA synthesis in coronaviruses part 76

FUTURE ISSUES:

  • In vitro reconstitution of the RTC core complex will allow the study of the coronavirus proofreading mechanism, the temporal or spatial regulation of proofreading and capping activities, which share several viral components, and the role of N protein RNA chaperone activity
  • Understanding the interaction of cell and viral protein within the nucleus, and of nuclear proteins traveling to the cytoplasm to interact with viral factors, may provide novel avenues to clarify coronavirus replication
  • It is still unknown whether replication and transcription are simultaneous or sequential processes

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