Continuous and discontinuous RNA synthesis in coronaviruses part 75

Future issues:

  • Further research is required on cis-acting elements involved in replication and transcription, and on the viral and cellular proteins that bind them
  • The function and dynamics of DMVs and CMs and the precise localization of the sites of active viral RNA synthesis remain unresolved questions
  • The contribution of cytoplasmic RNA-protein complexes containing viral RNAs,  such as stress granules, to the regulation of coronavirus RNA expression requires further research
  • Limited information is available on the temporal regulation of viral translation, replication, and transcription over the course of infection and on how switching between these processes occurs


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