Continuous and discontinuous RNA synthesis in coronaviruses part 74

SUMMARY POINTS:

  • Coronavirus cis-acting RNA elements involved in RNA synthesis are mainly located in the highly structured 5′ and 3’UTRs
  • The replicase proteins nsp7, nsp8, nsp12, and nsp14 may constitute an RTC core complex
  • Coronaviruses encode a proofreading machinery, unique among the RNA viruses, to ensure the maintenance of their large genome size. The ExoN activity of nsp14 is a key element of the proofreading system

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