Continuous and discontinuous RNA synthesis in coronaviruses part 72

Summary points:

  • Coronavirus express their 3′-proximal ORFs through a collection of overlapping, nested sgmRNAs generated by a mechanism of discontinuous transcription unique among RNA viruses. This process includes a template switch during the synthesis of negative-strand sgRNAs to add a copy of the leader  sequence
  • Coronavirus transcription is regulated by multiple factors, including the extent of base-pairing between the complement of the TRS-B in the nascent negative strand and the TRS-L as well as protein RNA and RNA-RNA interactions. Moreover, coronavirus N protein RNA chaperone activities essential for efficient transcription.

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