Continuous and discontinuous RNA synthesis in coronaviruses part 65

Coronavirus nsp14 ExoN activity was proposed to be part of an RNA proofreading machinery during coronavirus replication, and accumulating data support this role. Phylogenetically, only long-size nidovirus genomes encode an ExoN activity, and acquisition of this activity seems crucial to allow nidovirus genome expansion. The discovery of insect nidoviruses with a 20-kb RNA genome, encoding ExoN function, strongly reinforced this idea.

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