Continuous and discontinuous RNA synthesis in coronaviruses part 60

The nsp7-nsp8-nsp12 complex formed in vitro is able to catalyze de novo synthesis of relatively long RNAs (up to 340 nt) in a processive manner. Also interacting with nsp8 is nsp9, a small protein that binds ssRNA without sequence specificity. Dimerization of nsp9 is critical for virus replication, and its structural and functional features strongly suggest that it could be a component of the RTC catalytic core, stabilizing viral RNAs during RNA synthesis and processing.

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