Continuous and discontinuous RNA synthesis in coronaviruses part 58

The RdRp domain, located in the C-terminal region of nsp12, contains all conserved motifs of canonical RdRps, including the palm, fingers, and thumb domains. In addition to the RdRp domain, nsp12 also contains an N-terminal domain that is essential for RdRp activity and probably interacts with nsp5, nsp8, and nsp9. In vitro, full-length nsp12 drives RNA synthesis in a primer-dependent manner on both homo- and heteropolymeric RNA templates. However, the in vitro nsp12 RdRp activity is weak and nonprocessive, in contrast with the efficient replication of the RNA genome in vivo.

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