Continuous and discontinuous RNA synthesis in coronaviruses part 55

In this new conformation, the 3′ end of the genome is recognized by the RdRp and associated factors, promoting the initiation of negative-strand RNA synthesis. Further studies are required to confirm this model and to analize whether or not alpha- and gammacoronaviruses, which lack either the BSL or the PK, respectively, employ a similar molecular switch mechanism.

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