In this new conformation, the 3′ end of the genome is recognized by the RdRp and associated factors, promoting the initiation of negative-strand RNA synthesis. Further studies are required to confirm this model and to analize whether or not alpha- and gammacoronaviruses, which lack either the BSL or the PK, respectively, employ a similar molecular switch mechanism.
Continuous and discontinuous RNA synthesis in coronaviruses part 55
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