In addition, evidence for a direct interaction of the PK loop 1 (L1) with the 3′ end of the genome and with nsp8 and nsp9 has been reported. Based of these studies, a model for the initiation of coronavirus negative-strand RNA synthesis was proposed. In this model, the binding of a protein complex (including nsp8 and nsp9) to the stem formed by base-pairing of the PK L1 and the 3′ end of the genome may cause a conformational shift that leaves free the 3′ end of the genome and disrupts the lower stem of the BSL, leading to the formation of the PK.
Continuous and discontinuous RNA synthesis in coronaviruses part 54
This entry was posted in Tak Berkategori. Bookmark the permalink.