Finally, a higher-order RNA structure (SL5) that extends into ORF1a seems to be conserved within specific coronavirus genera. In alphacoronaviruses, SL5 may be further subdivided into three hairpins (SL5a, SK5b, and SL5c), which are partially conserved in betacoronaviruses. In gammacoronaviruses, a possible SL5 is predicted to adopt a rod-like structure.