Continuous and discontinuous RNA synthesis in coronaviruses part 46

Other nuclear proteins, including the p100 transcriptional coactivator, PAPB, and certain members of the hnRNPs such as hnRNP Q, showed preferential binding to the 3′ end of the coronavirus genome and a positive effect on coronavirus RNA synthesis. The contribution of these proteins to host cell interactions in TGEV infection is supported by the formation of a complex including glyceraldehyde 3-phosphate dehydrogenase (GAPDH), glutamyl-prolyl-tRNA synthetase(EPRS), hn RNP Q, and the ribosomal protein L13a, which regulates the expression of inflammatory genes. Similarly, in infections by other RNA viruses, several nuclear proteins (La, Sam68, PTB, proteasome activator PA28γ, and nucleolin) also relocalized to the cytoplasm and were involved in virus replication.

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