Continuous and discontinuous RNA synthesis in coronaviruses part 45

Coronavirus and arterivirus, like those from other cytoplasmic RNA viruses, interact with host cell proteins, modifying their nuclear-cytoplasmic localization and thereby affecting viral replication levels and modulating innate immune responses. Thus, nuclear proteins such as hnRNP A1 and PTB accumulate in the cytoplasm of cells infected by MHV and TGEV, respectively. These proteins bind to TRSs and to the 5′ end of the viral genome; PTB additionally reduces coronavirus RNA accumulation.

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