Continuous and discontinuous RNA synthesis in coronaviruses part 37



These granules contained the stress granule markers T cell intracellular antigen 1 (TIA-1), TIA-1-related protein (TIAR), and polypirimidine tract-binding protein (PTB) in association with with viral gRNA and sgmRNAs. TGEV-induced stress granules might contribute to the spatiotemporal regulation of viral RNA synthesis. Several stress granule proteins (including caprin and G3BP) have been associated with IBV N protein, pointing to nthe relevance of these RNA-protein complexes in the regulation of coronavirus gene expression.




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