STRESS GRANULES AND PROCESSING  BODIES IN REPLICATION-TRANSCRIPTION COMPLEX ACTIVITY

Stress granules and processing (P) bodies are cytoplasmic RNA granules that contain translationally silenced messenger ribonucleoproteins, contributing to translation regulation in cells. Whereas P bodies are constitutively expressed and include components involved in mRNA decay, stress granules are though to be sites of mRNA storage and triage formed in response to stress conditions. Stress granules represent an intermediate stage in the dynamic equilibrium between active translation on free polysomes and mRNA decay in P bodies.