Continuous and discontinuous RNA synthesis in coronaviruses part 33

030320_coronavirus_image_from_cdc

 

The function and dynamics of DMVs and CMs and the precise localization of the sites of active viral RNA synthesis are still unresolved questions, and further studies are required. A possible model proposes that DMVs may be the initial sites of active RNA synthesis early in infection, whereas at later times, after membrane connections are lost, RNA synthesis shifts to the CMs, and DMVs become end-stage products that sequester  nonfuctional dsRNAs to prevent the stimulation of the innate immune response.

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