Continuous and discontinuous RNA synthesis in coronaviruses part 28




Like that of other positive-strand RNA viruses, coronavirus RNA synthesis is associated with extensively rearranged intracellular membranes. High-resolution three-dimensional images obtained by electron tomography in SARS-CoV-infected cells showed a unique reticulovesicular network of modified endoplasmic reticulum that integrated convoluted membranes (CMs), interconnected double-membrane vesicles (DMVs), and vesicle packets apparently rising from DMV merger.

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