Continuous and discontinuous RNA synthesis in coronaviruses part 27

030320_coronavirus_image_from_cdc

 

Alteration of coronavirus frame-shifting efficiency modified the ratio of replicase proteins, affecting viral RNA synthesis and virus production. In this sense, regulation of the ratio between the two vira lpolymerasess nsp8 and nsp12, encoded by ORF1a and ORF1b, respectively, may be involved in controlling the levels of the different sgmRNAs during viral RNA synthesis.

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