Continuous and discontinuous RNA synthesis in coronaviruses part 25


As components of the coronavirus RTC, cell proteins can also modulate sgmRNA ratios. Infectious bronchitis virus (IBV) N protein  was recently shown to recruit  cellular helicase DDX1 to viral RTCs, facilitating TRS read-through and synthesis of long sgmRNAs. Interestingly, DDX1 recruitment requires N protein phosphorylation by cellular GSK3 kinase. Thus, the cell factor DDX1, attracted by phosphorilated N protein, provides a unique strategy for the transition from discontinuous to continuous transcription in coronaviruses to ensure balanced sgmRNA and full-length gRNA synthesis.


About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s