Continuous and discontinuous RNA synthesis in coronaviruses part 20

030320_coronavirus_image_from_cdc

This interaction could bring into physical proximity the leader sequence, at the genome 5’end, and the TRS-N, which would promote the template switch during synthesis of the negative-strand sgRNAs. This long-distance RNA-RNA interaction provided for the first time experimental support of the physical proximity between TRS-L and a TRS-B during discontinuous transcription in order to promote efficient RdRp transfer.

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