Continuous and discontinuous RNA synthesis in coronaviruses part 19

030320_coronavirus_image_from_cdc

 

The amount of sgmRNA N produced is directly proportional to the extent of the complementarity between pE and dE and inversely proportional to the distance between them. This interaction is probably necessary to relocate the active domain, another cis-acting RNA motif, consisting of a 173-nt region at the 5’flank of dE, immmediately preceding the CS-N. The second long-distance RNA-RNA interaction is held between a 10-nt sequence within the active domain and a complementary RNA motif located at the 5’end of the viral genome (nucleotides 477 to 486), more than 25,000 nt apart, and represents the longest-distance RNA-RNA interaction reported so far in the RNA virus world.

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