Continuous and discontinuous RNA synthesis in coronaviruses part 18

030320_coronavirus_image_from_cdc

 

In TGEV, two intragenomic, long-distance RNA-RNA interactions have been described to regulate the transcription of sgmRNA [coding for the nucleocapsid protein (N protein)], which is the most abundant sgmRNA during viral infection despite its low ΔG value for TRS-L-TRS-B duplex formation. The first interaction is established between two         complementary 9-nt cis-acting elements preceding the CS of the N gene, the proximal element (pE) and the distal element (dE), which are located 7 and 449 nt upstream of the CS-N, respectively.

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