Continuous and discontinuous RNA synthesis in coronaviruses part 16

030320_coronavirus_image_from_cdc

 

These observations provided experimental evidence for the selection of the TRS-L during the template switch, excluding other genome TRS-Bs that contain the CS. Only the CS-L, located in a sequence context with optimal secondary structure and stability for template switching, may act as a landing site for the newly synthesized negative-strand RNA.

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