Continuous and discontinuous RNA synthesis in coronaviruses part 13

030320_coronavirus_image_from_cdc

 

RNA sequences regulating transcription

The transcription process is controlled by transcription-regulating sequences (TRSs) located at the 3′ end of the leader sequence (TRS-L) and preceding each viral gene (TRS-B). TRSs include a conserved core sequence (CS) 6-7 nt in length  and variable 5′ and 3′ flanking sequences (the 5’TRS and 3’TRS , respectively). Because the CS is identical for the genome leader (CS-L) and all mRNA  coding sequences (CS-B), the CS-L could base-pair with the nascent negative strand complementary to each CS-B (cCS-B), allowing for leader-body joining.

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