Continuous and discontinuous RNA synthesis in coronaviruses part 11



The observation raises the question of whether the presence of the leader sequence in coronavirus sgmRNAs provides any selective advantage to the virus. The presence of the 5′ leader sequence was shown to protect SARS-CoV mRNAs from nsp1-induced endonucleolytic cleavage of capped mRNAs, providing a strategy for the efficient accumulation of viral mRNAs and viral proteins during infection.

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