Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 57

030320_coronavirus_image_from_cdc

 

The investigation note that most SARS-CoV neutralizing Abs  isolated to date target the SB domain and that several of them recognize the RBM and prevent receptor engagement. As the SARS-CoV-2 and SARS-CoV SB domains share  75% amino acid sequence identity, future work will be necessary to evaluate whether any of these Abs neutralize the newly emerged coronavirus.

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