Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 56

030320_coronavirus_image_from_cdc

 

The investigation surmise most of these Abs target the highly conserved S2 subunit  (including the fusion peptide region) based on its structural similarity  across SARS-CoV-2 and SARS-CoV, the lack of crosss-reactivity of several SB-directed Abs, and previous reports showing that sera from SARS-CoV-infected individuals target this region.

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