Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 43

030320_coronavirus_image_from_cdc

 

These observations:

  • The fact that some, but not all, of these viruses use ACE2 as entry receptor
  • That the S1 subunit is more exposed at the viral surface than the fusion machinery and is likely to be subject to a more stringent selection pressure from the immune system

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