Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 30

030320_coronavirus_image_from_cdc

 

To understand the contribution of receptor interaction to the infectivity of SARS-CoV-2, the investigation characterized engagement of hACE2 by SARS-CoV-2 SB and SARS-CoV SB side by side. The investigation used biolayer interferometry to study binding kinetics and affinity of the purified hACE2 ectodomain to SARS-CoV-2 SB and SARS-CoV SB immobilized at the surface of biosensors.

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