Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 26

030320_coronavirus_image_from_cdc

 

SARS-CoV-2 Sfur/mut preserves only the concerved arginin residue at position 685 of wild-type SARS-CoV-2 S, thereby mimicking the S1/S2 furine cleavage site of the related SARSr-CoV S CZX21. SARS-CoV-2 Sfur/mut is therefore expected to undergo processing at the S1/S2 site upon encountering a target cell, similar to SARS-CoV S and SARSr-CoV S, i.e., via TMPRSS2 and/or cathepsin  L.

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