Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 25

030320_coronavirus_image_from_cdc

 

 

To study the influence on pseudovirus entry of the SARS-CoV-2 S1/S2 furin cleavage site, it designed an S mutant lacking the four amino acid residue   insertion and the furin cleavage site by mutating   Q677TNSPRRARSV687 (wild-type SARS-CoV-2 S) to Q677TILRSV683 (SARS-CoV-2 Sfur/mut).

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